BRMs Biologic Response Modifiers

Many arthritis treatments target the signs and symptoms of disease, but a class of medications called biologic response modifiers (BRMs) actually stops disease progression and, in many cases, initiates a long-lasting remission. Infact, these drugs often work for people in whom other therapies have failed. Studies show that two-thirds of people with RA respond favorably – some dramatically – to a BRM. In many cases, BRMs are used together with standard DMARDs, such asmethotrexate.

Although the BRMs work in different ways, all inhibit proteins called cytokines, which contribute to inflammation. Adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) block a cytokine called tumor necrosis factor- alpha (TNF-a); anakinra (Kineret) blocks a cytokine called interleukin-1 (IL-1).

Like many drugs, BRMs have a downside, most often, expense. Also, the drugs must be infused intravenously or injected. Researchers say that future agents may be less expensive and taken orally.

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