BRMs Biologic Response Modifiers

Many arthritis treatments target the signs and symptoms of disease, but a class of medications called biologic response modifiers (BRMs) actually stops disease progression and, in many cases, initiates a long-lasting remission. Infact, these drugs often work for people in whom other therapies have failed. Studies show that two-thirds of people with RA respond favorably – some dramatically – to a BRM. In many cases, BRMs are used together with standard DMARDs, such asmethotrexate.

Although the BRMs work in different ways, all inhibit proteins called cytokines, which contribute to inflammation. Adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) block a cytokine called tumor necrosis factor- alpha (TNF-a); anakinra (Kineret) blocks a cytokine called interleukin-1 (IL-1).

Like many drugs, BRMs have a downside, most often, expense. Also, the drugs must be infused intravenously or injected. Researchers say that future agents may be less expensive and taken orally.

Arthritis News

Treatment Of Psoriatic Arthritis - Humira (Adalimumab) Approved In Europe

"Until today, the options for patients and physicians seeking an effective medication to treat both the joint and skin aspects of psoriatic arthritis were limited," said Serge Steinfeld, M.D...

Long-standing rheumatoid arthritis - Adalimumab plus methotrexate effective

For people with long-standing rheumatoid arthritis, combined treatment with the new "biologic" drug adalimumab and methotrexate is about five times more effective than methotrexate alone, ac...

Arthritis of the spine often overlooked in children

When kids or teens experience aching joints and stiffness it may be more than growing pains. It may be arthritis of the spine and other joints (ankylosing spondylitis), which researchers report can of...